Dr. med. Tim Wehner

1994 – 2001
Studium der Humanmedizin, Universität Witten/Herdecke, Auslandsaufenthalte in Aberdeen, UK, und Cleveland, OH, USA


Promotion zum Dr. med., Abteilung für experimentelle Neurologie, Charité, Berlin, Prof. Dr. U. Dirnagl

2001 – 2002
Wissenschaftlicher Mitarbeiter, Studiendekanat, Universität Witten/Herdecke; Mitarbeit bei der Etablierung des Reformstudiengangs Medizin

2002 – 2011

Weiterbildung zum Neurologen und Epileptologen, MetroHealth Medical Center, Cleveland, OH, USA (2002 – 2003), Cleveland Clinic, Cleveland, OH, USA (2003 – 2008), Universitätsklinikum Marburg (2008 – 2011), Vitos-Klinik für Psychiatrie, Marburg (2010)


Diplom, American Board of Psychiatry und Neurology


Facharzt für Neurologie

2011 – 2017

Consultant Neurologist and Clinical Neurophysiologist, and Honorary Senior Lecturer, Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, University College London, London, UK

Seit Februar 2017

Oberarzt der Ruhr-Epileptologie an der Neurologischen Klinik

Ellen Thomas Award for Epilepsy Research

  • Dt. Gesellschaft für Epileptologie (Zertifikat Epileptologie plus)
  • Dt. Gesellschaft für klinische Neurophysiologie (EEG-Zertifikat)
  • Dt. Gesellschaft für Neurologie

Seit 2003
Vorlesungen, Seminare, und Unterricht am Krankenbett im Rahmen des Medizinstudiums.
Praktikum Neurologie (6. und 10. Semester)
PJ – Beauftragter der Neurologischen Klinik
Faculty, Biannual ILAE Teaching Course for Epilepsy, Oxford, UK

Wissenschaftliche Arbeiten

Popkirov S, Grönheit W, Jungilligens J, Wehner T, Schlegel U, Wellmer J. Suggestive seizure induction for inpatients with suspected psychogenic nonepileptic seizures. Epilepsia 2020;doi: 10.1111/epi.16629. Online ahead of print

Grönheit W, Popkirov S, Wehner T, Schlegel U, Wellmer J. Practical management of epileptic seizures and status epilepticus in adult palliative care patients. Front. Neurol. 2018;9:595. doi: 10.3389/fneur.2018.00595

Wehner T, Mannan S, Turaga S, Vallabhaneni K, Yip HM, Wiggans C, Shankar R,Duncan JS, Sander JW. Retention of perampanel in adults with pharmacoresistant epilepsy at a single tertiary care center. Epilepsy Behav. 2017;73: 106 - 110

Sparks R, Vakharia V, Rodionov R, Vos SB, Diehl B, Wehner T, Miserocchi A,McEvoy AW, Duncan JS, Ourselin S. Anatomy-driven multiple trajectory planning (ADMTP) of intracranial electrodes for epilepsy surgery. Int J Comput Assist Radiol Surg. 2017;12: 1245 - 1255

Aurangzeb S, Symmonds M, Knight RK, Kennett R, Wehner T, Irani SR. LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures. Seizure 2017;50: 14 - 17

Shankar R, Henley W, Wehner T, Wiggans C, McLean B, Pace A, Mohan M, Sadler M, Doran Z, Hudson S, Allard J, Sander JW. Perampanel in the general population and in people with intellectual disability: Differing responses. Seizure 2017;49: 30 - 35

Sharma NK, Pedreira C, Centeno M, Chaudhary UJ, Wehner T, França LGS, Yadee T, Murta T, Leite M, Vos SB, Ourselin S, Diehl B, Lemieux L. A novel scheme for the validation of an automated classification method for epileptic spikes by comparison with multiple observers. Clin Neurophysiol. 2017;128: 1246 - 1254

Gooneratne IK, Mannan S, de Tisi J, Gonzalez JC, McEvoy AW, Miserocchi A, Diehl B, Wehner T, Bell GS, Sander JW, Duncan JS. Somatic complications of epilepsy surgery over 25 years at a single center. Epilepsy Res. 2017;132: 70 - 77

Gollwitzer S, Scott CA, Farrell F, Bell GS, de Tisi J, Walker MC, Wehner T, Sander JW, Hamer HM, Diehl B. The long-term course of temporal lobe epilepsy: From unilateral to bilateral interictal epileptiform discharges in repeated video-EEG monitorings. Epilepsy Behav. 2017;68: 17 - 21

Carreño M, Bien CG, Asadi-Pooya AA, Sperling M, Marusic P, Elisak M, Pimentel J, Wehner T, Mohanraj R, Uranga J, Gómez-Ibáñez A, Villanueva V, Gil F, Donaire A, Bargalló N, Rumià J, Roldán P, Setoain X, Pintor L, Boget T, Bailles E, Falip M, Aparicio J, Dalmau J, Graus F. Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies. Epilepsy Res. 2017;129: 101 - 105

Sparks R, Zombori G, Rodionov R, Nowell M, Vos SB, Zuluaga MA, Diehl B, Wehner T, Miserocchi A, McEvoy AW, Duncan JS, Ourselin S. Automated multiple trajectory planning algorithm for the placement of stereo-electroencephalography (SEEG) electrodes in epilepsy treatment. Int J Comput Assist Radiol Surg. 2017;12: 123 - 136

Nowell M, Sparks R, Zombori G, Miserocchi A, Rodionov R, Diehl B, Wehner T, White M, Ourselin S, McEvoy A, Duncan J. Resection planning in extratemporal epilepsy surgery using 3D multimodality imaging and intraoperative MRI. Br J Neurosurg. 2016;8: 1 - 3

Franko E, Wehner T, Joly O, Lowe J, Porter MC, Kenny J, Thompson A, Rudge P, Collinge J, Mead S. Quantitative EEG parameters correlate with the progression of human prion diseases. J Neurol Neurosurg Psychiatry 2016;87: 1061 - 1067

Gollwitzer S, Valente I, Rodionov R, Scott C, Ritter LM, Wehner T, Hamer HM, Bartolomei F, Diehl B. Visual and semiautomated evaluation of epileptogenicity in focal cortical dysplasias - An intracranial EEG study. Epilepsy Behav. 2016;58: 69 - 75

Whitehead K, Gollwitzer S, Millward H, Wehner T, Scott C, Diehl B. The additional lateralizing and localizing value of the postictal EEG in frontal lobe epilepsy. Clin Neurophysiol. 2016;127: 1774 - 1780

Nowell M, Sparks R, Zombori G, Miserocchi A, Rodionov R, Diehl B, Wehner T, Baio G, Trevisi G, Tisdall M, Ourselin S, McEvoy AW, Duncan J. Comparison of computer-assisted planning and manual planning for depth electrode implantations in epilepsy. J Neurosurg. 2015;4: 1 - 9

Varley J, Wehner T, Sisodiya S. Diaphragm myoclonus followed by generalized atonia in a patient with trisomy 4p: unusual semiology in an unusual condition. Epileptic Disord. 2015;17: 473 - 477

Baraldi S, Farrell F, Benson J, Diehl B, Wehner T, Kovac S. Drop attacks, falls and atonic seizures in the Video-EEG monitoring unit. Seizure 2015;32: 4 - 8

Fois C, Kovac S, Khalil A, Tekgöl Uzuner G, Diehl B, Wehner T, Duncan JS, Walker MC. Predictors for being offered epilepsy surgery: 5-year experience of a tertiary referral centre. J Neurol Neurosurg Psychiatry 2016;87: 209 - 211

Nowell M, Rodionov R, Zombori G, Sparks R, Winston G, Kinghorn J, Diehl B, Wehner T, Miserocchi A, McEvoy AW, Ourselin S, Duncan J. Utility of 3D multimodality imaging in the implantation of intracranial electrodes in epilepsy. Epilepsia 2015;56: 403 -413

Kovac S, Diehl B, Wehner T, Fois C, Toms N, Walker MC, Duncan JS. Gelastic seizures: incidence, clinical and EEG features in adult patients undergoing video-EEG telemetry. Epilepsia 2015;56:e1 - 5

Wehner T, Chinnasami S, Novy J, Bell GS, Duncan JS, Sander JW. Long term retention of retigabine in a cohort of people with drug resistant epilepsy. Seizure 2014;23: 878 - 881

Nowell M, Rodionov R, Diehl B, Wehner T, Zombori G, Kinghorn J, Ourselin S, Duncan J, Miserocchi A, McEvoy A. A Novel Method for Implementation of Frameless StereoEEG in Epilepsy Surgery. Neurosurgery 2014;10 Suppl 4: 525 - 533

Perumal MB, Chinnasami S, Shah A, Rodionov R, Maglajlija V, Miserocchi A, McEvoy AW, Wehner T, Diehl B. Epileptic kinetopsia localizes to superior parietal lobule and intraparietal sulcus. Neurology 2014;83: 768 - 770

Kovac S, Chaudhary UJ, Rodionov R, Mantoan L, Scott CA, Lemieux L, Wehner T, Scherg M, Diehl B. Ictal EEG source imaging in frontal lobe epilepsy leads to improved lateralization compared with visual analysis. J Clin Neurophysiol. 2014;31: 10 - 20

Kovac S, Rodionov R, Chinnasami S, Wehner T, Scott CA, McEvoy AW, Miserocchi A, Diehl B. Clinical significance of nonhabitual seizures during intracranial EEG monitoring. Epilepsia 2014;55:e1 - 5

Unnwongse K, Alexopoulos AV, Busch RM, Wehner T, Nair D, Bingaman WE, Najm IM. Nonlesional atypical mesial temporal epilepsy: electroclinical and intracranial EEG findings. Neurology 2013;81: 1848 - 1855

Chapin JS, Busch RM, Silveira DC, Wehner T, Naugle RI, Ferguson L, Najm IM. Memory performance in older adults before and after temporal lobectomy for pharmacoresistant epilepsy. Clin Neuropsychol. 2013;27: 1316 - 1327

Rodionov R, Vollmar C, Nowell M, Miserocchi A, Wehner T, Micallef C, Zombori G, Ourselin S, Diehl B, McEvoy AW, Duncan JS. Feasibility of multimodal 3D neuroimaging to guide implantation of intracranial EEG electrodes. Epilepsy Res. 2013;107: 91 - 100

Teotónio R, Rodionov R, McEvoy AW, Duncan J, Diehl B, Wehner T. Ictal unilateral hyperkinetic proximal lower limb movements: an independent lateralising sign suggesting ipsilateral seizure onset. Epileptic Disord. 2013;15: 142 - 147

Kovac S, Nachev P, Rodionov R, Scott C, McEvoy AW, Toms N, Wehner T, Duncan JS, Diehl B. Neck atonia with a focal stimulation-induced seizure arising from the SMA: Pathophysiological considerations. Epilepsy and Behavior 2012;24: 503 - 506

Busch RM, Floden D, Lineweaver TT, Chapin JS, Unnwongse K, Wehner T, Diaz-Arrastia R, Najm IM. Effect of apolipoprotein ε4 allele on hippocampal and brain volume in intractable temporal lobe epilepsy. Epilepsy and Behavior 2011;21: 88 - 90

Wehner T
, Lachhwani DK, Bingaman W, Haspolat S, Gupta A, Kotagal P, Tuxhorn I, Wyllie E. Epilepsy surgery outcome in coexisting symptomatic refractory focal epilepsy and benign focal epilepsy of childhood. Pediatric Neurology 2011;44: 52 - 56

O'Dwyer R, Wehner T, Lapresto E, Ping L, Tkach J, Noachtar S, Diehl B. Differences in corpus callosum volume and diffusivity between temporal and frontal lobe epilepsy. Epilepsy and Behavior 2010;19: 376 - 382

Unnwongse K, Wehner T, Bingaman W, Foldvary-Schaefer N. Gelastic seizures and the anteromesial frontal lobe: A case report and review of intracranial EEG recording and electrocortical stimulation case studies. Epilepsia 2010;51: 2195 - 2198

Wehner T, Bauer S, Hamer HM, Hattemer K, Immisch I, Knake S, Nowak M, Reif PS, Strzelczyk A, Rosenow F. Six months postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany. Epilepsy and Behavior 2009;16: 423 - 425

Syed TU, Arozullah AM, Suciu GP, Toub J, Kim H, Dougherty ML, Wehner T, Stojic A, Syed I, Alexopoulos AV: Do observer and self-reports of ictal eye closure predict psychogenic nonepileptic seizures? Epilepsia 2008;49: 898 - 904

Wehner T, LaPresto E, Tkach J, Liu P, Bingaman W, Prayson RA, Ruggieri P, Diehl B: The value of interictal diffusion weighted imaging in lateralizing temporal lobe epilepsy. Neurology 2007;68: 122 - 127

Wehner T, Ross JS, Ransohoff RM: Fluid in the Flute – Reversible Hydromyelia. Journal of the Neurological Sciences 2005;236: 85 - 86

Wehner T, Bontert M, Eyupoglu I, Prass K, Prinz M, Klett FF, Heinze M, Bechmann I, Nitsch R, Kirchhoff F, Kettenmann H, Dirnagl U, Priller J: Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo. Journal of Neuroscience 2003;23: 5004 - 5011

Priller J, Flugel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernandez-Klett F, Prass K, Bechmann I, de Boer BA, Frotscher M, Kreutzberg GW, Persons DA, Dirnagl U: Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment. Nature Medicine 2001;7: 1356 - 1361

Bechmann I, Priller J, Kovac A, Böntert M, Wehner T, Fernandez-Klett F, Bohsung J, Stuschke M, Dirnagl U, Nitsch R: Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages. European Journal of Neuroscience 2001;14: 1651 - 1658


Irmen F, Wehner T, Lemieux L. Do reflex seizures and spontaneous seizures form a continuum? - triggering factors and possible common mechanisms. Seizure 2015;25: 72 - 79

Wehner T. The role of functional imaging in the tumor patient. Epilepsia. 2013;54;S9: 44 - 49

Unnwongse K, Wehner T, Foldvary-Schaefer N. Mesial frontal lobe epilepsy. Journal of Clinical Neurophysiology 2012;29: 371 - 378

Unnwongse K, Wehner T, Foldvary-Schaefer N. Selecting patients for epilepsy surgery. Current Neurology and Neuroscience Report 2010;10: 299 - 307

Wehner T, Hamer HM: Absetzen einer Antikonvulsivatherapie bei anfallsfreien Patienten. Neuro aktuell, 2010;188: 27 - 29

Wehner T, Lüders HO: Role of Neuroimaging in the Presurgical Evaluation of Epilepsy. Journal of Clinical Neurology 2008;4: 1 - 16


Wehner T, Unnwongse K, Diehl B: Focal epilepsy. In Mills KM (editor): Oxford Textbook of Clinical Neurophysiology, Oxford University Press, 2017

Wehner T & McEvoy A: Classification of seizures and epilepsy. In xxx (editor): Oxford Textbook of Neurosurgery, Oxford University Press, in press

Wehner T: Generalized tonic-clonic seizures. In Wyllie E (editor): The treatment of Epilepsy – Principles and Practice, 5th edition, Lippincott Williams & Wilkins, Philadelphia, 2011

Wehner T, Knake S, Grant PE: Structural imaging of mesial temporal lobe epilepsy. In Rosenow F, Lüders H, Ryvlin P (editors): The mesial temporal lobe epilepsies, John Libbey Eurotext, Paris, 2011

Perampanel in a real-world setting – Making Waves Series, Manchester, UK, September 2017

How to differentiate epileptic and nonepileptic seizures on clinical grounds – Brighton, UK, December 2016

Epilepsy – A network disease – Indian Epilepsy School, Hyderabad, Indien, September 2015

Epilepsy – more than seizures counts – Annual Meeting of the Thai Neurological Society, Bangkok, Thailand, July 2015

Role of functional neuroimaging in people with focal epilepsy in the setting of low grade brain neoplasms – International Epilepsy Symposium, Cleveland, OH, USA, May 2013

Pitfalls in Epilepsy Surgery – Annual meeting of the Thai Neurological Society, Bangkok, Thailand, July 2011

Withdrawing Anticonvulsants in People with Epilepsy who are Seizure free – Prasat Neurological Institute Grand Rounds, Bangkok, Thailand, Nov 2010

Absetzen einer Antikonvulsivatherapie – Fortbildungsakademie der 6. gemeinsamen Jahrestagung der Deutschen, Österreichischen und Schweizerischen Sektionen der Internationalen Liga gegen Epilepsie, Rostock, Mai 2009

Mesial Temporal Sclerosis – primary and secondary MRI criteria - 1st International Epilepsy Colloquium, Marburg, Juni 2008

Presurgical Evaluation of Pharmacoresistant Epilepsy – Cleveland Clinic / Yeditepe University Epilepsy Course, Istanbul, Turkey, September 2007
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